Fuel cell technology is promising to become a realistic alternative to conventional combustion-based powertrains and pure battery electric vehicles. With polymer electrolyte membrane (PEM) fuel cells, driving ranges and refueling durations comparable to conventional combustion-based vehicles can be achieved, while operating free of emissions and providing CO2 neutrality in case hydrogen from renewable sources is used. AVL will present a degradation focused insight on its take on system simulation, displaying simulation analysis for live cycle aging as well as discussing parametrization methodology based on state-of-the art industry use cases.